Human ASH1 expression in prostate cancer with neuroendocrine differentiation
نویسندگان
چکیده
منابع مشابه
Neuroendocrine differentiation in prostate cancer.
As any organ in the body human prostate is composed of many different types of cells as well as extracellular components. During prostate development, reciprocal cellular interactions between stromal cells and prostate epithelial cells ultimately lead to the development of a mature prostate. Normal prostate is composed of repeating cellular units that contain stromal and epithelial compartments...
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RATIONALE About 95% of prostate cancers are adenocarcinoamas. Depending on the detection method used, neuroendocrine cells are found in 10% to 100% of prostate cancer specimens. OBJECTIVE A 64-year-old patient was diagnosed in 2006 with adenocarcinoma of the prostate, PSA 4.1 ng/ml, Gleason 6, T3b, positive PSA immunohistochemistry. METHODS AND RESULTS The patient was started on hormone the...
متن کاملNeuroendocrine differentiation of prostate cancer.
Global Objectives: Review recent advances in the identification and diagnosis of current and emerging disease states. Discuss the pathophysiology of various disease states and the multidisciplinary considerations that affect patient care outcomes. Identify recent changes in requirements for accreditation, licensing, and regulatory compliance in across all divisions of pathology. Discuss...
متن کاملNeuroendocrine differentiation of prostate cancer: a review.
Neuroendocrine cells are one of the epithelial populations in the prostate. Neuroendocrine differentiation (NED) has been observed in prostate cancer. In addition to small cell neuroendocrine carcinomas and carcinoid tumors of the prostate, prostatic adenocarcinomas may have NED. The incidence and clinical relevance of NED in prostatic adenocarcinoma is not clearly understood because of conflic...
متن کاملAndrogen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation
Most prostate cancers (PCas) are classified as acinar type (conventional) adenocarcinoma which are composed of tumor cells with luminal differentiation including the expression of androgen receptor (AR) and prostate-specific antigen (PSA). There are also scattered neuroendocrine (NE) cells in every case of adenocarcinoma. The NE cells are quiesecent, do not express AR or PSA, and their function...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2008
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.2008.39